Job Description:

Modeling & Simulation (M&S) methodologies plays an increasingly important role in the development of new drugs within Vertex Pharmaceuticals. We are seeking an Associate Director, Modeling & Simulations to add to our Modeling & Simulations group. The successful candidate will combine strong pharmacometric skills with a deep biological understanding and will be responsible for developing and executing M&S strategies and activities in cross functional drug development project teams in close collaboration with colleagues in Clinical Pharmacology, Biostatistics, Research and other colleagues within the R&D organization.

Key responsibilities:
  • Development and execution of Modeling & Simulation plans and analyses fully integrated with the overall development plans
  • By using state of the art Modeling & Simulation methodologies, strongly contribute to critical decision making like study design, dose selection, probability of success estimation etc.
  • Independently perform mechanism based PKPD and population PK and PKPD-analyses, Clinical trial simulations and other model based analyses on a regular basis.
  • Contribute to the continuous improvement in efficiency and effectiveness of our M&S capability by supporting training activities, evaluating and incorporating new M&S tools as appropriate.
Preferred Qualifications:

  • Experience working in clinical development teams and integrating the use of PK/PD modeling and/or modeling of complex biological system

Qualification:

  • PhD in Pharmaceutical sciences, Pharmacometrics, Clinical pharmacology, mathematics, statistics, or other quantitative discipline with an emphasis on Pharmacometrics and PKPD modeling
  • 5+ yrs post PhD hands-on experience in the application of Pharmacometric and other Modeling methodologies in the context of drug research & development in industry, academia or regulatory agencies.
  • A solid understanding of biology, pharmacokinetic and quantitative pharmacology (PKPD) principles.
  • Excellent hands-on skills in population PK and PKPD modeling, mechanistic PKPD modeling, Clinical trial simulations, Disease progression modeling etc.
  • Excellent skills in the use of NonMem, PsN, R, Phoenix, and similar tools
  • Demonstrated strong leadership-, collaborative and influencing skills
  • Excellent, verbal and written communication skills
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Associated topics: bioengineering, biomaterials, biomedical engineer, biosynthetic, metabolic, molecular, neurodegenerative, nutrition, pathogenesis, therapeutic

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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