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Job Description:

We are seeking an exceptional scientist and leader to join our Drug Metabolism and Pharmacokinetics (DMPK) team in Boston. As a Director/Fellow, you will develop scientific strategies, lead and mentor a team, and build partnerships cross-functionally to advance Vertex's programs. You will be part of the global and local DMPK site leadership teams and help advance discovery and development of groundbreaking therapies for serious unmet medical needs.

Key Responsibilities:

  • Develop and execute scientific strategies to address ADME challenges on discovery and development programs
  • Build and maintain strong collaborative partnerships with Medicinal Chemistry, Biology, Preclinical Safety, Clinical Pharmacology, CMC and other R&D disciplines to advance Vertex programs through discovery and development
  • Represent DMPK function on drug discovery and development teams and at Vertex R & D governance bodies
  • Implement creative DMPK technologies and approaches to enhance scientific impact and/or efficiencies
  • Provides scientific and/or managerial leadership to their team in prioritizing and executing on key deliverables and project needs
  • Ensure completion of necessary DMPK regulatory documentation and reports to support drug development including Investigator Brochures, INDs (or equivalent), and marketing applications
  • Hire, develop, mentor, manage and retain key talent to maintain a high-performing team
  • Develop internal and external sourcing strategies and liaise across sites to best meet portfolio needs
  • Contribute to developing Global DMPK resource allocation, staffing needs, expenses, and capital budget and implementation plans
  • Participate in assessment of business development opportunities


  • PhD or equivalent, with >10 years of experience working in a managerial/leadership or a senior scientific role as part of a multifunctional DMPK group in a pharmaceutical company
  • Deep understanding of the drug discovery and development process and cross-functional dependencies
  • Deep scientific and strategic expertise in various components of predictive and translational DMPK science such as in vitro and in vivo ADME, mass spectrometry and bioanalysis, pharmacokinetic data analysis and interpretation, biotransformation/disposition pathways, drug interaction risk assessment and human pharmacokinetics and dose predictions
  • Additional skills and familiarity in areas such as transporter science, enzymology, chemistry, and PK/PD and PBPK modeling will be a strong plus
  • Successful track record and experience in a DMPK lead role on multiple R & D teams across more than one therapeutic area
  • Strong mentoring and leadership skills, with emphasis on developing and coaching junior scientists to build a high-performing team
  • Ability to stay abreast and critically evaluate scientific literature and new technology as it relates to the discovery and development of new medicines
  • Excellent verbal, written and interpersonal communication skills, and ability to develop and grow strong cross-site/function collaborations

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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