Job Description:

We are seeking a computational biologist with expertise in making biological discoveries by leveraging large-scale genomic data to join Vertex’s research site in Boston, MA. This position is part of a growing global Computational Genomics team focused on developing gene editing and genetic therapy treatments of serious human diseases. Your key tasks will be to collaborate with cross-functional project teams to design studies, analyze and interpret large-scale genomics data, and communicate results that will have critical impact on the development of cutting-edge, transformative therapies. You will play a key role in bringing together the needs of project teams with state-of-the-art computational biology tools, which will require proactive communication and seamless collaboration with both computational and experimental team members.

Key responsibilities:
  • Collaborate with project teams, acting as the computational biology expert, to identify key needs and questions that can be addressed using genomics, sequencing, or bioinformatics contributions
  • Plan studies leveraging sequencing, genetic, and genomic data to answer biological questions and enable development of genetic therapy treatments
  • Plan, execute, and iterate on analysis of large-scale sequencing data, in partnership with computational and experimental team members
  • Visualize, summarize, and communicate findings to project teams and other key stakeholders
  • Follow cutting-edge advancements in the fast-paced fields of gene editing and genetic therapies, bringing developments in-house or building upon them as appropriate
  • Partner with method development team members to improve or expand computational methods


Minimum Qualifications:
  • PhD degree in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field
  • A proven track record in the analysis, visualization, and interpretation of genomic and next-generation sequencing (NGS) data
  • Demonstrated ability to work closely with project teams and/or experimental collaborators to design studies and develop analyses to answer scientific questions
  • Solid scientific understanding of gene editing, the role of genetic variation in human disease, molecular biology, and cellular biology
  • Expertise with applying computational methods and bioinformatics tools to large-scale data; proficiency with R, Python, Linux/Unix systems, high-performance computing systems; solid understanding of statistics
  • Detail-oriented and self-motivated approach to problem solving with excellent reasoning skills
  • A team-oriented growth mindset that welcomes feedback from others and supports other team members; strong collaboration skills to work across teams and functions
  • A positive attitude that enthusiastically tackles and overcomes challenges
  • Strong organizational and time-management skills to prioritize needs and get things done
  • Excellent presentation and communication skills, including the ability to tailor scientific content to audiences with different backgrounds

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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