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Job Description:

We seek a highly motivated and innovative scientist with a passion to apply biophysical techniques to drug discovery. The ideal candidate will have a proven track record in biochemical and biophysical research including protein purification and expression, development of functional assays and structural studies on integral membrane protein. The Research Scientist will work within a team of biochemists, biophysicists and structural biologists in support of determining target mechanism of action and ligand engagement.

Key Responsibilities:
  • Expression and purification of integral membrane proteins for use in biophysical and functional assays and for structure determination  
  • Participate in experimental design and independently conducts experiments
  • Optimize and carry out biophysical protein-ligand measurements
  • Maintain clear records of experimental work and be able to organize, report and communicate their results

Qualification:

  • PhD in Structural Biology, Biochemistry, Biophysics or relevant field with 4+ years post-degree experience
  • Experience in protein expression from multiple organisms (mammalian, insect, bacterial, etc.)
  • Track record of protein purification of targets including membrane proteins and the use of manual and automated chromatography systems
  • Use of biochemical techniques (e.g. Western blot, SDS-PAGE, etc.) and experience with biophysical techniques an asset (e.g. SPR, MST, ITC, etc.)
  • Broad crystallization experience is desirable
  • Self-motivation, organization, effective communication and presentation skills
  • Ability to navigate a fast-paced work environment
  • A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society


* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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